Paclitaxel (trade name Taxo1) is a unique anti-tumor natural medicine in the genus Taxus. It was first isolated in 1971 by American chemists Wani and Wallt et al. and was officially approved by the US FDA in 1992. New anti-ovarian cancer drugs. Due to its unique anti-cancer mechanism and remarkable efficacy, it is considered to be the most significant discovery in the field of natural anticancer drugs in the past 15 years. With the deepening and improvement of paclitaxel research, chemical synthesis, genetic engineering, cell culture, fungal fermentation and other methods can successfully obtain paclitaxel, but the application of these methods to the production of paclitaxel remains at the laboratory research stage. At present, the commercial scale production of paclitaxel at home and abroad is mostly based on the yew plant, which is obtained through a series of separation and purification. Due to the extremely low content of paclitaxel in the bark of yew (<0.06%), it is difficult to extract and refine, which leads to the high price of pure paclitaxel. Therefore, perfecting the extraction and purification process of paclitaxel, reducing the production cost, and obtaining cheaper raw materials are of great significance for ensuring human health.
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Jinan Bona Biotechnology Co., Ltd. has developed SKS-30-3 alumina SKP-10-4300 chromatography resin for the separation and purification of paclitaxel by cooperation with research institutes and paclitaxel manufacturers, and has taken the lead in the extraction project. Ceramic filtration and nanofiltration make the original production process multiple extraction, three-step chromatography into two extraction two-step chromatography, so that the product purity of the product is increased to 98.5% or more, and the yield is increased by more than 20%. According to the properties of the product by-product, paclitaxel, the product is enriched and eluted with SKP-20-8300 chromatography resin to obtain a product with a purity of 99% or more.
1, 20 mesh or more dried yew methanol water leaching ceramic filter nanofiltration concentrate containing paclitaxel nanofiltration permeate containing taxol.
2. Nanofiltration concentrate extraction and concentration SKS-30-3 alumina conversion chromatography, staged collection of the required components, concentration recovery solvent, methanol water, dissolution, SKP-10-4300, chromatography resin, collection of the desired components, eluent, nanofiltration, concentration Crystallizes paclitaxel.
3. Nanofiltration permeate Concentration Brine dissolution SKP-20-8300 chromatography resin collects the desired components and concentrates to obtain taxol.
SKS-30-3 alumina SKP-10-4300 chromatography resin SKP-20-8300 chromatography resin is a new type of chromatography packing developed by Jinan Bona Biotechnology Co., Ltd. for paclitaxel extraction, SKP-10-4300 layer The separation of the resin and SKS-30-3 alumina can completely replace the high-pressure preparation liquid phase C18 separation and purification, so that the final purification of paclitaxel is no longer limited by the equipment, and the better separation of the product can be completed under low pressure conditions, including By-products such as taxanes 10-DABIII and 7-xylosyl groups. The treated taxol as a waste liquid is well separated.
Welcome to buy our company SKS-30-3 alumina SKP-10-4300 chromatography resin SKP-20-8300 chromatography resin, if you need to request experimental samples, please contact our company.